When you cry out to Him, does God hear your prayers?  What keeps Him from hearing your cries?  Isaiah the prophet warns “But your iniquities have made a separation between you and your God, and your sins have hidden His face from you so that He does not hear.”  (Isaiah 59:2)  Get alone with Him and deal with those hindrances to prayer, the sins in your life.  He promises that when we confess and forsake them He will forgive and cleanse us from all unrighteousness.  (I John 1:9)  James promises that “…the effective prayer of a righteous man can accomplish much.”  (James 5:16)